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Why We Need  
NR and NMN 
So you might be wondering: Why should I care? What does it matter that these molecules get into the cell a certain way or how they do it? NR and NMN are both beneficial because they elevate levels of NAD+, which decline with age. NAD+ is vital to metabolism, turning nutrients into energy, and it also activates sirtuins, a set of proteins that regulate longevity. We all get NAD+ in our bodies thanks to our diet, by consuming foods with NAD+ precursors in them. While NR and NMN can be found in trace amounts in various foods, though, one can’t eat enough of anything to boost NAD+ levels back to youthful levels. As a result, supplementing with a NAD+ precursor can help mitigate the decline. 
 
Supplementing NR and NMN could provide other myriad benefits as a result of boosting NAD+. NR supplementation in mice, for example, has proven beneficial for things like mitochondrial function. And NMN supplementation in mice has shown improved blood flow and endurance as well as other age-associated physiological decline like low energy and weight gain. Additional research is needed to confirm similar effects in humans. 
 
At the end of the day, though, what we know is that when compared to other precursors, NR is the most efficient of the bunch. The latest research on NMN could prime it to be the next great vitamin B3, but for now, more research in humans is needed to better understand how beneficial it could be and how it might stack up against NR. One possibility is that each precursor could provide varying benefits depending on the target, especially if transporters, like the recently discovered one in the gut, are only available in specific cells in the body. 
 
 
 
 
 
Blueberries 
Blueberries are the primary dietary source of pterostilbene. Study after study has shown that consuming blueberries can prevent and mitigate age-related cognitive disorders, and higher intakes of blueberries have been found to reduce the rate of cognitive decline. 
 
While blueberries contain numerous compounds that contribute to these cognitive benefits, pterostilbene is one of the most important contributing factors. Studies have shown that pterostilbene can improve cognition in rats. It has also been shown to help prevent the loss of the neurotransmitter dopamine from memory centers in aged rats. 
 
This is an example of how pterostilbene can battle the effects of age-related diseases. 
 
Pterostilbene Mimics Calorie Restriction 
Pterostilbene 
One mechanism by which calorie restriction has been shown to beneficially extend lifespan is by “turning on” genes directly related to long-term survival. Scientists have been intrigued to find that pterostilbene mimics many of the same broad preventive and therapeutic properties of calorie restriction. 
Studies show that a high intake of animal protein, particularly red meat, which contains high levels of methionine and BCAAs, may be related to the promotion of age-related diseases. Therefore, a low animal protein diet, particularly a diet low in red meat, may provide health benefits. However, malnutrition, including sarcopenia/frailty due to inadequate protein intake, is harmful to longevity/metabolic health. Therefore, further study is necessary to elucidate the specific restriction levels of individual AAs that are most effective for longevity/metabolic health in humans. 
Anti-Ageing Pathway mTOR 
A molecular complex called mammalian target of rapamycin (mTOR) is currently a major focus of pharmacological research to slow ageing, and for good reason. So far, reducing the expression of mTOR has been shown to extend lifespan across multiple species. Laboratory-bred mice whose expression of mTOR has been reduced to about 25% enjoy an approximate 20% increase in median lifespan. 
 
mTOR is a cellular signalling pathway that serves as a central regulator for cell growth, metabolism, survival, and proliferation. This pathway is responsible for controlling many of the processes that use or generate large amounts of energy and nutrients. When mTOR signalling goes awry, it triggers numerous harmful events, including those linked to a variety of cancers. 
 
Abnormal mTOR activation is a contributor to many of the chronic diseases of ageing. Scientists are aggressively seeking pharmaceutical approaches to lower the activity of mTOR. 
 
Pterostilbene (as well as other CR mimetics and calorie restricted diets) has been found to naturally inhibit the mTOR pathway. This reduction in mTOR provides a powerful way of regulating cellular growth and metabolism, and combating some of the primary factors involved in ageing and disease. 
 
pterostilbene impacts multiple antiaging factors involved in cardiovascular, hematologic, inflammatory, metabolic, and neurological disorders. Preclinical studies suggest that pterostilbene acts as a potent antitumor compound in multiple malignancies. 
 
Cell and animal studies have shown that pterostilbene can extend the lifespan of various animal models of human longevity by regulating three major pathways linked to longevity: mTOR, AMPK, and Sirtuins. 
There are a lot of unknowns about which doors may open for these precursors in the future, and what they could open up to, which only makes the field of ageing research more exciting. 
FREE POSTAGE within the UK 
Resveratrol
£19.99
Quantity:
90 capsules
100mg
NMN 
Nicotinamide Mononucleotide
£26.00
Quantity:
180 capsules
500mg
Check your blood levels 
When you start your journey on NMN, it's suggested you check your blood levels to check Methyl Donor Depletion, check your Homocysteine, Methionine and Betaine in blood, also your AST and ALT levels in your Liver. After 6 months taking NMN and Resveratrol, check your levels again to see if you have any change. 
 
Normal levels of AST and ALT may slightly vary depending on the individual laboratory's reference values. Typically the range for normal AST is reported between 10 to 40 units per litre and ALT between 7 to 56 units per litre. Mild elevations are generally considered to be 2-3 times higher than the normal range. 
 
Most laboratories report normal homocysteine levels in the blood between 4 and 15 micromoles/litre (µmol/L). Any measurement above 15 is considered high. Any measurement below 12 is considered low. Optimal homocysteine levels are below 10 to 12. 
 
The elderly often have low methionine intake, and studies have shown that they may need higher intakes of 2 to 3 grams per day ( 24 , 26 ). Despite the fact that certain groups may benefit from increasing their methionine intake, many diets exceed 2 grams per day of methionine plus cysteine. 
 
Resting concentrations of betaine in human serum range from ≈20 to 70 μmol/L with concentrations similar in diabetic subjects but lower in subjects with renal disease. High concentrations of betaine are found in human and animal neonates, probably because of choline metabolism 
 
Choline, containing phospholipids and other substances, like glycerophosphocholines, are transported in blood lipoproteins. Blood plasma choline levels in healthy fasting adults is 7 - 20 micromoles per litre (µmol/l) and 10 µmol/l on average. Levels are regulated, but choline intake and deficiency alters these levels. 
 
The capsule that holds the supplement  
For many who dislike swallowing the plastic like capsule as it's sometimes hard to digest, one can release the powder from the capsule and mix it with a glass of water, it's more gentle to ingest.  
 
The capsule that contains the NMN powder is made up of gelatin (hard or soft) and non-gelatin shells generally derived from hydrolysis of collagen (acid, alkaline, enzymatic, or thermal hydrolysis) from animal origin or cellulose based. 
longevity Formula
£95.00 £65.00
Fasting mimicking diet
Quantity:
Going without food if not done properly could be harmful.
 
Your SuperHuman pack is designed to help you reset your ageing clock, it will assist you on how to fast safely.
 
Your pack comes with scientific longevity supplements, Resveratrol and NMN, together with your specially designed food guide for when you are fasting, it also contains a food guide on meals that heal.
NMN high purity powder is better, the powder in the capsules are of the highest purity of NMN. By taking the NMN powder under your tongue, it can be absorbed more efficient than the capsules. Each morning twist a capsule and pull it apart to release the powder. The powder can also be mixed with a glass of water to drink. In the latest research showing the benefits of NMN in mice, the mice consumed NMN mixed in the water they drank. 
 
NMN boosts NAD+ levels, promotes repair in damaged DNA. 
 
NMN increases cell vitality helping to support cognitive functions. 
Interview with Dr. David Sinclair from the Institute of Longevity. 
(statements below are taken from the interview) 
 
A scientific study over the past 10 years have shown, it’s not what you eat it’s when you eat. 
Mimicking with Molecules 
This is not just as effective but even better than intermittent fasting. 
 
Resveratrol from red wine, when given to fat mice they become as healthy as a thin mouse and they live just as long, they get heart disease and other associated diseases when they get old. 
 
Resveratrol given to mice every day and making them skip a meal, that combination showed the longest life span they’d ever seen in mice. 
 
When NMN was given to the mouse they found the mouse ran further than it could with just skipping a meal and taking Resveratrol.  
 
The set of genes that control ageing in yeast cells, genes called sirtuins, 7 of them in our bodies, 5 in yeast, they protect all organisms on the planet from deterioration and disease. They sense when we’re hungry, when we’re exercising and they send out the troops to defend us, so when you put more of these cells into a mouse it’ll live longer, between 5 to 20% longer. NMN and Resveratrol are these molecules. 
 
Resveratrol is the accelerator pedal for the sirtuins genes and NMN is the fuel. Without the fuel the accelerator won’t work and vice versa. 
 
NR and NMN raises the molecule NAD, sirtuins needs NAD for it to work, if you don’t have NAD in your body you’d be dead in 30 seconds, it’s really important. 
 
But as we get older we lose NAD and when you reach 50 you’ll have half the levels of what you had when you were 20. 
 
Sirtuins don’t protect your body without NAD, and NMN boosts the body’s levels back up to healthy amounts. 1 gram NMN in morning based on clinical trials, half gram Resveratrol. 1 gram Metformin. 
 
METFORMIN prevents cancer, heart disease, Alzheimer's and ageing, it’s been shown through scientific studies the body is protected against these diseases, even frailty in old age.  
 
Ageing isn’t classified as a disease yet, so a doctor will not be able to prescribe you Metformin. 
 
Universal regulators of ageing  
There are 3 main pathways  
(1) Metformin activates AMPK which will send out the troops if you are ill. 
(2) Sirtuins - NMN raises the molecule NAD vital to metabolism, turning nutrients into energy. 
(3) Lower the activity of mTOR, a pathway that responds to amino acids, how much protein you’re eating, it’ll protect the body if you tweak it in the right way. 
 
Old theories about ageing, should be disregarded according to Dr. Sinclair.  
Free radicals, antioxidants, DNA damage, and mutations, is incorrect, antioxidants have failed in the anti-ageing world, Resveratrol is an antioxidant but doesn’t work like that in longevity, it steps on the accelerator pedal for sirtuins, so it’s directly controlling the bodies defences against ageing. 
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