Interview with Dr. David Sinclair from the Institute of Longevity.
(statements below are taken from the interview)
A scientific study over the past 10 years have shown, it’s not what you eat it’s when you eat.
Mimicking with Molecules
This is not just as effective but even better than intermittent fasting.
Resveratrol from red wine, when given to fat mice they become as healthy as a thin mouse and they live just as long, they get heart disease and other associated diseases when they get old.
Resveratrol given to mice every day and making them skip a meal, that combination showed the longest life span they’d ever seen in mice.
When NMN was given to the mouse they found the mouse ran further than it could with just skipping a meal and taking Resveratrol.
The set of genes that control ageing in yeast cells, genes called sirtuins, 7 of them in our bodies, 5 in yeast, they protect all organisms on the planet from deterioration and disease. They sense when we’re hungry, when we’re exercising and they send out the troops to defend us, so when you put more of these cells into a mouse it’ll live longer, between 5 to 20% longer. NMN and Resveratrol are these molecules.
Resveratrol is the accelerator pedal for the sirtuins genes and NMN is the fuel. Without the fuel the accelerator won’t work and vice versa.
NR and NMN raises the molecule NAD, sirtuins needs NAD for it to work, if you don’t have NAD in your body you’d be dead in 30 seconds, it’s really important.
But as we get older we lose NAD and when you reach 50 you’ll have half the levels of what you had when you were 20.
Sirtuins don’t protect your body without NAD, and NMN boosts the body’s levels back up to healthy amounts. 1 gram NMN in morning based on clinical trials, half gram Resveratrol. 1 gram Metformin.
METFORMIN prevents cancer, heart disease, Alzheimer's and ageing, it’s been shown through scientific studies the body is protected against these diseases, even frailty in old age.
Ageing isn’t classified as a disease yet, so a doctor will not be able to prescribe you Metformin.
Universal regulators of ageing
There are 3 main pathways
(1) Metformin activates AMPK which will send out the troops if you are ill.
(2) Sirtuins - NMN raises the molecule NAD vital to metabolism, turning nutrients into energy.
(3) Lower the activity of mTOR, a pathway that responds to amino acids, how much protein you’re eating, it’ll protect the body if you tweak it in the right way.
Old theories about ageing, should be disregarded according to Dr. Sinclair.
Free radicals, antioxidants, DNA damage, and mutations, is incorrect, antioxidants have failed in the anti-ageing world, Resveratrol is an antioxidant but doesn’t work like that in longevity, it steps on the accelerator pedal for sirtuins, so it’s directly controlling the bodies defences against ageing.