Activating Sirtuin 6 (essential for the over 60s)
(6) Fucoidan (seaweed)
(7) Oleic Acid
David Sinclair PhD
from Harvard Medical School,
his research on,
why we age -
and why we don't have to.
David says "I don't know 10-year-olds that get Alzheimer's disease or heart disease, but these diseases are common in old age.
We have 16 researchers in the academy, all have been working on this for most, if not all, of our careers. So that spans, for many of us, over 25 years. When we started, research on ageing at the molecular level was the backwater of biology, but in the last 25 years, ageing has moved to the forefront of science. It’s actually rare to open a leading scientific journal and not see a new breakthrough in our understanding of the ageing process.
There are two molecules that are special and find their way into the cell in a unique way, and as a result these molecules increased the endurence and lifespan in mice. NR and NMN are these molecules and they are both beneficial because they elevate levels of NAD+, which decline with age. NAD+ is vital to metabolism, turning nutrients into energy, and it also activates sirtuins, a set of genes that regulate longevity. Activating Sirtuin 6, it has now been pinpointed that sirtuin 6 is the gene responsible to elevate NAD+ levels. We all possess NAD+ in our bodies thanks to our diet, by consuming foods with NAD+ precursors in them. While NR and NMN can be found in trace amounts in various foods, though, one can’t eat enough of anything to boost NAD+ levels back to youthful amounts. As a result, supplementing with a NAD+ precursor can help mitigate the decline. According to David Sinclair NMN is better than NR showing a higher more improved blood flow and endurance than NR.
Supplementing with NR and NMN could provide other myriad benefits as a result of boosting NAD+. NR and NMN supplementation in mice, for example, has proven beneficial for things like mitochondrial function. And NMN has shown improved blood flow and endurance as well as other age-associated physiological decline like low energy and weight gain. Additional research is needed to confirm similar effects in humans.
At the end of the day, though, what we know is that when compared to other precursors, NR and NMN are the most efficient of the bunch. The latest research however on NMN could prime it to be the next great generation, the new kid on the block.
NMN has shown to boost NAD+ levels and promote repair in damaged DNA, increases cell vitality helping to support cognitive functions., but for now, more research in humans is needed to better understand how beneficial it could be and how it might stack up against NR. One possibility is that each precursor could provide varying benefits depending on the target, especially if transporters, like the recently discovered one in the gut, are only available in specific cells in the body.
Resveratrol is the accelerator pedal for the sirtuins genes and NMN is the fuel.
The generally recommended dosage of Nicotinamide Mononucleotide is anywhere between 50mg to1g per day. As this is an expensive compound to produce and cost is an issue for many people, Science behind Longevity recommend a dosage of 50mg to 100mg per day, for the over 60's it's better to have a smaller quantity in your system than not to take the compound at all.
Compared to commonly used tablets, capsules and other oral dosage forms, sublingual absorption is generally much faster and more efficient. Peak blood levels of most products administered in a sublingual way are achieved within 10‐15 minutes, which is generally much faster than when those same compounds are ingested orally.
Per gram our prices are the lowest you'll find.
What is NMN?
NMN occurs naturally in the body and is found in dietary sources such as fruits, milk, and vegetables, however these dietary sources do not contain high enough amounts to keep your body at youthful amounts as you begin to age. NMN is used to generate nicotinamide adenine dinucleotide (NAD+), a powerful and essential molecule that is found in every cell of the body, this in turn activates a set of sirtuins genes that protect your body against disease.
The appearance of Trans Resveratrol 98-99% is an off white powder with a slight yellow cast, not brown in colour. Sometimes you hear about “resveratrol,” sometimes you hear about “trans resveratrol,” and sometimes you hear about “pure resveratrol.” They are not all the same thing.
Resveratrol is the general product name for a supplement sold in different levels of purity. Trans resveratrol, on the other hand, is the active ingredient in a resveratrol supplement. In other words, resveratrol products contain varying percentages of the active ingredient trans resveratrol. Some branded products are only 5 percent pure, while others might be 25 percent, 50 percent, or 75 percent pure.
Most resveratrol found on store shelves in the U.S. contains 50 percent or less of the active ingredient. Since it is a dietary supplement, the Food and Drug Administration does not regulate the labelling of such products in terms of their purity. So consumers must beware!
Because you cannot be sure how much trans resveratrol your supplement contains, always be sure to buy pure trans resveratrol.
What is Pure Trans Resveratrol?
Pure trans resveratrol is a resveratrol product that is at least 98-99 percent comprised of the active ingredient- trans-resveratrol. Resveratrol occurs naturally in such plants and plant products as dark chocolate, tea leaves, certain berries, grapes, peanuts and Japanese knotweed, which is then purified to various purities, anywhere from 5 percent to 99 percent pure. Pure trans resveratrol may cost more, but it contains effective dosages of the active ingredient, unlike many competitors, 5 to 10 percent pure, which are essentially useless.
Pure trans resveratrol has numerous health benefits, as mentioned above. These include protection against heart-attacks and strokes, anti-ageing and anti-inflammatory properties, , macular-degeneration and cataracts, and cancer-fighting properties.
In addition to trans resveratrol, low purity resveratrol supplements contain “cis resveratrol,” which likewise occurs naturally in the same plant products as does trans resveratrol. However, cis resveratrol has no known beneficial health properties. Most lower quality supplements contain large quantities of this useless cousin of trans resveratrol.
MORE ways of turning on SERT6
Quercetin is a plant pigment (flavonoid). It is found in many plants and foods, such as red wine, onions, green tea, apples, berries, Ginkgo biloba, St. John's wort, American elder, and others. Buckwheat tea has a large amount of quercetin.
Fisetin tetrahydroxyflavone, is a bioactive flavonol molecule found in fruits and vegetables such as strawberry, apple, persimmon, grape, onion, and cucumber.
Apigenin trihydroxyflavone), found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides.
Niacin, also known as nicotinic acid, is an organic compound and a form of vitamin B₃, an essential human nutrient. It can be manufactured by plants and animals from the amino acid tryptophan.
Activating Sirtuin 6
(6) Fucoidan (seaweed)
(7) Oleic Acid
The dose suggested is a guide only, it is imperative you consult your GP before taking any of the supplements listed.
Reverse ageing in skin, reduce wrinkles
Red Light Therapy
Wave length 390 – 640 (nanometers)
NIR light therapy helps reverse signs of skin aging, including fine lines, wrinkles, sun spots, and sagging, papery skin. In the deeper layers of the skin, NIR increases collagen and elastin production. Elastin is a key protein of the extracellular matrix. It is highly elastic and present in connective tissue allowing many tissues in the body to resume their shape after stretching or contracting. In humans, elastin is encoded by the ELN gene. This restores the thickness, firmness, and elasticity of youthful skin.
LED – NIR and LED – RL = 20 minute sessions
Vitamin A Acid = Retinoic acid cream
Promotes mitochondria cells
Promotes collagen and stem cells reducing age related wrinkles in the skin.
Retinol is a type of retinoid which is not the same and does not possess the same effects.
Collagen peptides are also good to keep skin youthful.
Berberine = replaces metformin, helping your insulin sensitivity factor.
425mg take every other day.
Magnesium Tourate 100 mg take occasionally
Niacin B₃ 100 mg take occasionally
Quercetin 500 mg take 250 mg daily
Trans Resveratrol & NMN
Old theories about ageing, should be disregarded according to Dr. Sinclair.
Free radicals, antioxidants, DNA damage, and mutations, is incorrect, antioxidants have failed in the anti-ageing world.
Resveratrol is an antioxidant but doesn’t work like that in longevity, it steps on the accelerator pedal for sirtuins, so it’s directly controlling the bodies defences against ageing.
Make sure the powder you buy is at least 98 - 99% pure powder.
Pure powder is better than capsules. By taking the NMN powder under your tongue, it can be absorbed more efficiently than taking capsules.
A study in aging mice demonstrated that supplementing with NMN prevented age-associated genetic changes and improved energy metabolism, physical activity, and insulin sensitivity.
NAD+ decline is thought to be associated with accelerated physical decline and the onset of age-related diseases like Alzheimer’s.
Animal studies have shown that supplementing with NAD+ precursor NMN restores NAD+ levels and prevents age-related physical decline.
Resveratrol is a polyphenol in grapes, berries and red wine that may promote longevity by activating certain genes called sirtuins. It has been shown to increase the lifespan of mice, fruit flies, yeasts, and nematodes.
Turning on genes connected to long term survival. Mimicking with molecules has been found to be better than intermittent fasting by controlling calorie restriction.
Anti-Ageing Pathway mTOR
A molecular complex called mammalian target of rapamycin (mTOR) is currently a major focus of pharmacological research to slow ageing, and for good reason. So far, reducing the expression of mTOR has been shown to extend lifespan across multiple species. Laboratory-bred mice whose expression of mTOR has been reduced to about 25% enjoy an approximate 20% increase in median lifespan.
mTOR is a cellular signalling pathway that serves as a central regulator for cell growth, metabolism, survival, and proliferation. This pathway is responsible for controlling many of the processes that use or generate large amounts of energy and nutrients. When mTOR signalling goes awry, it triggers numerous harmful events, including those linked to a variety of cancers.
Abnormal mTOR activation is a contributor to many of the chronic diseases of ageing. Scientists are aggressively seeking pharmaceutical approaches to lower the activity of mTOR.
Pterostilbene (as well as other CR mimetics and calorie restricted diets) has been found to naturally inhibit the mTOR pathway. This reduction in mTOR provides a powerful way of regulating cellular growth and metabolism, and combating some of the primary factors involved in ageing and disease.
pterostilbene impacts multiple antiaging factors involved in cardiovascular, hematologic, inflammatory, metabolic, and neurological disorders. Preclinical studies suggest that pterostilbene acts as a potent antitumor compound in multiple malignancies.
Cell and animal studies have shown that pterostilbene can extend the lifespan of various animal models of human longevity by regulating three major pathways linked to longevity: mTOR, AMPK, and Sirtuins. There are a lot of unknowns about which doors may open for these precursors in the future, and what they could open up to, which only makes the field of ageing research more exciting.
What is olive oil good for?
Olive Oil Contains Large Amounts of Antioxidants
These antioxidants are biologically active and reduce your risk of chronic diseases. They also fight inflammation and help protect your blood cholesterol from oxidation, two benefits that may lower your risk of heart disease. Dr. Gundry recommends cold-pressed, extra virgin high-polyphenol olive oil. He has not come out and recommended a specific brand, but in 2019 he did launch his own, Gundry MD high polyphenol olive oil.
Olivar Santamaria Extra Virgin Olive Oil from Picual olives have some of the highest levels of polyphenols.
Studies show that a high intake of animal protein, particularly red meat, which contains high levels of methionine and BCAAs, may be related to the promotion of age-related diseases. Therefore, a low animal protein diet, particularly a diet low in red meat, may provide health benefits. However, malnutrition, including sarcopenia/frailty due to inadequate protein intake, is harmful to longevity/metabolic health. Therefore, further study is necessary to elucidate the specific restriction levels of individual AAs that are most effective for longevity/metabolic health in humans.
Check your blood levels
When you start your journey on NMN, it's suggested you check your blood levels to check Methyl Donor Depletion, check your Homocysteine, Methionine and Betaine in blood, also your AST and ALT levels in your Liver. After 6 months taking NMN and Resveratrol, check your levels again to see if you have any change.
Normal levels of AST and ALT may slightly vary depending on the individual laboratory's reference values. Typically the range for normal AST is reported between 10 to 40 units per litre and ALT between 7 to 56 units per litre. Mild elevations are generally considered to be 2-3 times higher than the normal range.
Most laboratories report normal homocysteine levels in the blood between 4 and 15 micromoles/litre (µmol/L). Any measurement above 15 is considered high. Any measurement below 12 is considered low. Optimal homocysteine levels are below 10 to 12.
The elderly often have low methionine intake, and studies have shown that they may need higher intakes of 2 to 3 grams per day ( 24 , 26 ). Despite the fact that certain groups may benefit from increasing their methionine intake, many diets exceed 2 grams per day of methionine plus cysteine.
Resting concentrations of betaine in human serum range from ≈20 to 70 μmol/L with concentrations similar in diabetic subjects but lower in subjects with renal disease. High concentrations of betaine are found in human and animal neonates, probably because of choline metabolism
Choline, containing phospholipids and other substances, like glycerophosphocholines, are transported in blood lipoproteins. Blood plasma choline levels in healthy fasting adults is 7 - 20 micromoles per litre (µmol/l) and 10 µmol/l on average. Levels are regulated, but choline intake and deficiency alters these levels.
NR (Nicotinamide Riboside Side Effects)
Some people have reported mild to moderate side effects, such as nausea, fatigue, headaches, diarrhea, stomach discomfort and indigestion, if this is the case cut out high sugary sweet foods. In animals, taking 300 mg per kg of body weight (136 mg per pound) daily for 90 days had no harmful effects but they did not have high sugar in their diet.
Also the capsule itself maybe another reason behind why some people feel nausea and report indigestion, as this part although not made of plastic it does have that feel to it, it's unpleasant to swallow and can take time to digest.
The capsule that holds the supplement
For many who dislike swallowing the plastic like capsule as it's sometimes hard to digest, one can release the powder from the capsule and mix it with a glass of water, it's more gentle to ingest.
The capsule that contains the powder is made up of gelatin (hard or soft) and non-gelatin shells generally derived from hydrolysis of collagen (acid, alkaline, enzymatic, or thermal hydrolysis) from animal origin or cellulose based.
Resveratrol combined with NMN
Interview with Dr. David Sinclair
NMN high purity powder is better than capsules. By taking the NMN powder under your tongue, it can be absorbed more efficiently than taking the capsules, and the capsule itself over a period of time will bcome hard to digest. Either buy pure powder or each morning twist a capsule and pull it apart to release the powder.
In the latest research showing the benefits of NMN in mice, the mice consumed NMN mixed in their water they drank, however some of the powder will stick to the side of the glass so be careful not to waste any of the valuable powder, it's best to measure your dosage and put the powder in a spoon to consume, let the powder melt in your mouth before you drink the water.
NMN boosts NAD+ levels, promotes repair in damaged DNA.
NMN increases cell vitality helping to support cognitive functions.
Dr. David Sinclair from Harvard Medical School.
A scientific study over the past 10 years have shown, it’s not what you eat it’s when you eat.
Mimicking with Molecules
This is not just as effective but even better than intermittent fasting.
Resveratrol from red wine, when given to fat mice they become as healthy as a thin mouse and they live just as long, they get heart disease and other associated diseases when they get old.
Resveratrol given to mice every day and making them skip a meal, that combination showed the longest life span they’d ever seen in mice.
When NMN was given to the mouse they found the mouse ran further than it could with just skipping a meal and taking Resveratrol.
The set of genes that control ageing in yeast cells, genes called sirtuins, 7 of them in our bodies, 5 in yeast, they protect all organisms on the planet from deterioration and disease. They sense when we’re hungry, when we’re exercising and they send out the troops to defend us, so when you put more of these cells into a mouse it’ll live longer, between 5 to 20% longer.
NR and NMN raises the molecule NAD+, sirtuins needs NAD+ for it to work, if you don’t have NAD+ in your body you’d be dead in 30 seconds, it’s really important.
But as we get older we lose NAD+ and when you reach 50 you’ll have half the levels of what you had when you were 20.
Sirtuins - NMN raises the molecule NAD+ vital to metabolism, turning nutrients into energy.
Lower the activity of mTOR, a pathway that responds to amino acids, how much protein you’re eating, it’ll protect the body if you tweak it in the right way.
Old theories about ageing, should be disregarded according to Dr. Sinclair.
Free radicals, antioxidants, DNA damage, and mutations, is incorrect, antioxidants have failed in the anti-ageing world, Resveratrol is an antioxidant but doesn’t work like that in longevity, it steps on the accelerator pedal for sirtuins, so it’s directly controlling the bodies defences against ageing.
Ageing, which can be defined as the “time-related deterioration of the physiological functions necessary for survival and fertility,” is a process that most people would like to slow.
Some of its main causes include accumulated cellular damage caused by reactive molecules known as free radicals and the shortening of telomere, which are the structures located at the ends of chromosomes that play an important role in cellular division.
While ageing is inevitable, increasing the human lifespan and slowing the ageing process has been a focus of scientific research for decades.
Through that research, scientists have identified a large number of substances that have anti-aging properties, many of which can be taken as supplements by those looking for natural ways to decelerate the ageing process and prevent age-related disease.
Note that this list is not exhaustive, and many other supplements may also offer anti-ageing effects.
Here are supplements with anti-ageing properties.
Curcumin the main active compound in turmeric, has been shown to possess powerful anti-aging properties, which are attributed to its potent antioxidant potential.
Cellular senescence occurs when cells stop dividing. As you age, senescent cells accumulate, which is believed to accelerate aging and disease progression.
Research demonstrates that curcumin activates certain proteins, including sirtuins and AMP-activated protein kinase (AMPK), which helps delay cellular senescence and promotes longevity.
Plus, curcumin has been shown to combat cellular damage and significantly increase the lifespan of fruit flies, roundworms, and mice. This compound has been shown to postpone age-related disease and alleviate age-related symptoms as well.
This may be why turmeric intake has been associated with a reduced risk of age-related mental decline in humans. You can increase your curcumin intake by using turmeric in recipes or taking curcumin supplements.
Curcumin is the main active compound in turmeric. It may slow ageing by activating certain proteins and protecting against cellular damage.
Epigallocatechin gallate (EGCG) is a well-known polyphenol compound concentrated in green tea. It offers impressive health benefits, with research supporting its use to reduce the risk of certain cancers, as well as other health conditions like heart disease.
Among EGCG’s diverse array of potential health-promoting properties is its ability to promote longevity and protect against age-related disease development.
EGCG may slow ageing by restoring mitochondrial function in cells and acting on pathways involved in aging, including the AMP-activated protein kinase signalling pathway (AMPK).
It also induces autophagy, the process by which your body removes damaged cellular material.
Green tea intake has been associated with a reduced risk of all-cause mortality, diabetes, stroke, and heart-disease-related death. Plus, animal studies have shown that it can protect against skin aging and wrinkles caused by ultraviolet (UV) light.
EGCG can be consumed by drinking green tea or taking concentrated supplements.
EGCG is a polyphenol compound concentrated in green tea that may improve mitochondrial function and promote autophagy. Green tea intake has been linked to a reduced risk of all-cause mortality.
Collagen is promoted as a fountain of youth for its potential to reduce the appearance of skin aging.
It’s an integral component of your skin that helps maintain skin structure. As you age, collagen production slows, leading to collagen loss in the skin that accelerates signs of aging like wrinkles.
Some research suggests that supplementing with collagen may reduce signs of aging, including wrinkles and dry skin.
For example, a 2019 study in 72 women demonstrated that taking a supplement that contained 2.5 grams of collagen, along with several other ingredients, including biotin, per day for 12 weeks significantly improved skin hydration, roughness, and elasticity.
Another study in 114 women found that treatment with 2.5 grams of collagen peptides for 8 weeks significantly reduced eye wrinkles and increased collagen levels in the skin.
Though these results are promising, keep in mind that many collagen studies are funded by companies that manufacture collagen products, which may influence study results.
Many types of collagen supplements are on the market, including powders and capsules.
Collagen is a popular dietary supplement that may help prevent skin ageing by boosting collagen levels in your skin.
Coenzyme Q10 (CoQ10) is an antioxidant that your body produces. It plays essential roles in energy production and protects against cellular damage.
Research suggests that levels of CoQ10 decline as you age, and supplementing with it has been shown to improve certain aspects of health in older individuals.
For example, a study in 443 older adults demonstrated that supplementing with CoQ10 and selenium over 4 years improved their overall quality of life, reduced hospital visits, and slowed the deterioration of physical and mental performance.
CoQ10 supplements help reduce oxidative stress, a condition characterized by an accumulation of free radicals and other reactive molecules that accelerates the ageing process and onset of age-related disease. Though CoQ10 shows promise as an anti-ageing supplement, more evidence is needed before it can be recommended as a natural way to delay ageing.
Be sure to consult a trusted healthcare professional before giving it a try. CoQ10 is an important antioxidant that your body naturally produces. Some research shows that supplementing with it may slow age-related physical decline and improve quality of life in older adults.
10 SCIENTIFIC STEPS TO A LONGER LIFE
1. enjoy healthy food without over eating
2. never over sleep but get adequate sleep that suits you
3. be active, with a daily gentle walking routine
4. meditate to free your mind of busy activity
5. breathing meditation is also beneficial
6. abstain from food occasionally
7. experience cold conditions from time to time
8. protect your skin from ultraviolet radiation
9. yoga stretching exercises to keep supple and in trim
10. scientific supplements
Nicotinamide riboside and nicotinamide mononucleotide
Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are precursors to nicotinamide adenine dinucleotide (NAD+).
NAD+ is a compound found in every cell in your body and involved in many critical processes, including energy metabolism, DNA repair, and gene expression.
NAD+ levels decline with age, and this decline is thought to be associated with accelerated physical decline and the onset of age-related diseases like Alzheimer’s.
Animal studies have shown that supplementing with NAD+ precursors NMN and NR restores NAD+ levels and prevents age-related physical decline.
For example, a study in aging mice demonstrated that supplementing orally with NMN prevented age-associated genetic changes and improved energy metabolism, physical activity, and insulin sensitivity.
Additionally, a 2019 study in 12 men with an average age of 75 showed that supplementing with 1 gram of NR daily for 21 days increased NAD+ levels in skeletal muscle and reduced levels of inflammatory proteins in the body.
However, one of the authors in the study above owns stock in and serves as an advisor to the company that manufactured the NR supplement being studied, which may have skewed results.
A number of other animal studies have shown positive results related to supplementing with both NR and NMN. However, more human research is needed before strong conclusions on the anti-ageing effects of NR and NMN can be made.
Supplementing with NMR and NR may help boost NAD+ levels in your body and prevent age-associated genetic changes.
Crocin is a yellow carotenoid pigment in saffron, a popular, pricey spice that’s commonly used in Indian and Spanish cuisine.
Human and animal studies have shown that crocin offers many health benefits, including anticancer, anti-inflammatory, anti-anxiety, and anti-diabetic effects.
Aside from the properties listed above, crocin has been researched for its potential to act as an anti-ageing compound and protect against age-related mental decline.
Test-tube and rodent studies have demonstrated that crocin helps prevent age-related nerve damage by inhibiting the production of advanced glycation end products (AGEs) and reactive oxygen species (ROS), which are compounds that contribute to the ageing process.
Crocin has also been shown to help prevent aging in human skin cells by reducing inflammation and protecting against UV-light-induced cellular damage.
Given that saffron is the most expensive spice in the world, a more cost-effective way to boost your crocin intake is by taking a concentrated saffron supplement.
Crocin, which is a pigment found in the spice saffron, shows promise as an anti-aging supplement. It may prevent cellular damage and reduce inflammation, which may promote longevity and prevent mental decline.
Theanine. L-theanine is an amino acid concentrated in certain teas, including green tea. It may help protect against mental decline and has been shown to extend the lifespan of roundworms by around 5%.
Rhodiola. This medicinal plant has potent anti-inflammatory and anti-aging properties. One study in fruit flies demonstrated that treatment with Rhodiola rosea powder led to a 17% increase in their lifespan, on average.
Garlic. Garlic has powerful anti-inflammatory and antioxidant properties. Test-tube and rodent studies have shown that supplementing with this bulb may prevent UV-light-induced skin aging and wrinkles.
Astragalus. Astragalus membranaceus is a stress-reducing herb used in traditional Chinese medicine. It may help combat ageing by reducing oxidative stress, promoting immune function, and preventing cellular damage.
Fisetin. Fisetin tetrahydroxyflavone) is a dietary flavonoid found in various fruits (strawberries, apples, mangoes, persimmons, kiwis, and grapes), vegetables (tomatoes, onions, and cucumbers), nuts, and wine that has shown strong anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic. Fisetin is a flavonoid compound that’s considered a senotherapeutic, meaning it can kill senescent cells. Rodent studies suggest that it may reduce the number of senescent cells in tissues and extend lifespan.
Resveratrol. Resveratrol is a polyphenol in grapes, berries, peanuts, and red wine that may promote longevity by activating certain genes called sirtuins. It has been shown to increase the lifespan of fruit flies, yeasts, and nematodes.
Though these results are promising, more research in humans is needed to fully understand how these supplements may be used to promote longevity.
Research has shown that L-theanine, Rhodiola rosea, garlic, Astragalus membranaceus, fisetin, and resveratrol are supplements that may have anti-aging properties.
Pterostilbene Mimics Calorie Restriction
One mechanism by which calorie restriction has been shown to beneficially extend lifespan is by “turning on” genes directly related to long-term survival. Scientists have been intrigued to find that pterostilbene mimics many of the same broad preventive and therapeutic properties of calorie restriction.
Blueberries are the primary dietary source of pterostilbene. Study after study has shown that consuming pterostilbene can prevent and mitigate age-related cognitive disorders, and higher intakes of blueberries have been found to reduce the rate of cognitive decline.
Pterostilbene is one of the most important contributing factors. Studies have shown that pterostilbene can improve cognition in rats. It has also been shown to help prevent the loss of the neurotransmitter dopamine from memory centers in aged rats. This is an example of how pterostilbene can battle the effects of age-related diseases.
In natural medicine, blueberry extract is said to have a number of health benefits. It is said to boost the health of blood vessels and is often used to treat or prevent the following conditions: Age-related macular degeneration. Alzheimer's disease. The amount of blueberries you'd need to consume for any benefits to take place would be quite large amounts, therefore by consuming the supplement Pterostilbene which is a potent polyphenol, the benefits would be much greater. This supplement is produced by Science behind Longevity.
Recipe for home baked cakes without sugar
8oz self raising Flour
4oz vegetable fat suitable for home baking
Half a small cupful of semi skimmed milk
you could add stevia or manuka honey if you prefer your cake to be more sweet.
Electric whisk the mixture until a thick creamy consistency, put mixture in cake tin and oven bake until cooked.
GOOD Foods and teas you can have everyday
Green tea, mint tea, lemon tea, hibiscus tea,
Make sure your soups are low in sugar...
Tomato soup, minestrone soup, vegetable soup, mushroom soup.
nuts – cashews, walnuts, quinoa, peas, carrot juice, spinach, watercress.
Antioxidants are molecules which can safely interact with free radicals and terminate the chain reaction before vital molecules are damaged. Although there are several enzyme systems within the body that disarm free radicals, the principal antioxidants are vitamin E, beta-carotene, selenium and vitamin C, however it is not good to take too much vitamin C and do not take it regularly, it's water soluble so use the time release and keep it to 1000mg, and only take them to help combat a cold, vitamin C with zinc zaps a cold.
The best fruits are the ones that are more sour or yellow, red and bluish-black coloured when ripe: oranges, apricots, grapefruit, tangerines, blackberries, blueberries, black grapes, black plums, strawberries, cherries, yellow-fleshed peaches, pineapple, kiwi, persimmons. The peel or skin contains larger amounts of antioxidants than the pulp. It is also advisable to eat the peel of citrus fruits (only if organic), which is rich in antioxidants. Carrot juice mixed with ginger.
Dark chocolate is rich in flavonoid antioxidants, including it in a well-balanced diet can tackle the cognitive decline, improve brain functions, make the thinking process faster and improve short-term and long-term memory.
NR and NMN
These molecules are special and find their way into the cell in a unique way, NR and NMN are both beneficial because they elevate levels of NAD+, which decline with age. NAD+ is vital to metabolism, turning nutrients into energy, and it also activates sirtuins, a set of proteins that regulate longevity. We all possess NAD+ in our bodies thanks to our diet, by consuming foods with NAD+ precursors in them. While NR and NMN can be found in trace amounts in various foods, though, one can’t eat enough of anything to boost NAD+ levels back to youthful amounts. As a result, supplementing with a NAD+ precursor can help mitigate the decline.